Table 4.

Median Area Under the Concentration-Time Curve for Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol, by Weight Band in Children Treated for Tuberculosis

	AUC24, Median (IQR), mg⋅h/L
Weight Band, kg	Rifampicin (n = 77)	Isoniazid (n = 76)	Pyrazinamide (n = 45)	Ethambutol (n = 22)
4–7.9	20.1 (15.2–34.6) [n = 16]	11.9 (8.4–22.4) [n = 16]	242 (174–299) [n = 14]	7.6 (7.1–8.6) [n = 7]
8–11.9	28.3(23.4– 40.3) [ n = 14]	20.9 (16.5–28.5) [n = 14]	322 (247–490) [n = 11]	6.9 (4.7–11.0) [n = 6]
12–15.9	42.0 (27.0–54.2) [n = 16]	21.0 (17.5–33.3) [ n = 16]	385 (313–490) [n = 7]	11.6 (10.5–13.0) [n = 4]
16–24.9	49.8 (34.3–70.3) [n = 16]	21.5 (14.1–32.8) [n = 15]	434 (315–454) [n = 7]	11.7 (11.5–16.9) [n = 3]
≥25	21.6 (12.4–32.8) [n = 15]	5.8 (3.5–8.8) [n = 15]	339 (293–369) [n = 6]	10.4 (9.2–11.5) [n = 2]

Abbreviations: AUC₂₄, area under the concentration-time curve from 0 to 24 hours; IQR, interquartile range.