Table 1.
Parasite Clearance Time (Hours) by Treatment Group
| Cipargamin Dose/Regimen | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 10 mg QD | 25 mg QD | 50 mg QD | |||||||
| 10 mg SD (n = 10) | 3 days (n = 10) | 25 mg SD (n = 12) | 3 days (n = 20) | 50 mg SD (n = 21) | 3 days (n = 19) | 75 mg SD (n = 21) | 150 mg SD (n = 22) | Artemether-lumefantrine (n = 51) | |
| Median PCT | 24.4 | 30.1 | 11.6 | 8.1 | 8.2 | 8.2 | 8.0 | 8.1 | 24.3 |
| (2-sided 95% CI) | (8.0, 48.0) | (4.2, 36.7) | (8.0, 24.0) | (8.0, 12.2) | (8.0, 12.2) | (8.0, 12.0) | (8.0, 8.1) | (2.1, 9.2) | (24.1, 36.0) |
PCT was calculated from the date of first treatment and is based on uncorrected parasite counts. Patients without parasite clearance for whatever reason are censored at the time of last parasite assessment. In the case that a patient receives rescue medication before parasite clearance, the time to event is censored at the first use of rescue medication.
Abbreviations: CI, confidence interval; PCT, parasite clearance time; QD, daily; SD, single dose.