Table 2.
Occurrence of Recrudescence With PfATP4 G358S Mutation, by Dose Regimen
| Patients, n (%) | |||
|---|---|---|---|
| Dose regimen | Number of Patients | Late Treatment Failures | Recrudescences With G358S Mutation |
| Cipargamin 10 mg SD | 9 | 1 (11) | 0 (–) |
| Cipargamin 25 mg SD | 12 | 4 (33) | 0 (–) |
| Cipargamin 50 mg SD | 21 | 4 (19) | 4 (19) |
| Cipargamin 75 mg SD | 20 | 5 (25) | 3 (15) |
| Cipargamin 150 mg SD | 22 | 9 (41) | 5 (23) |
| Cipargamin 10 mg QD 3 days | 10 | 1 (10) | 1 (10) |
| Cipargamin 25 mg QD 3 days | 20 | 4 (20) | 3 (15) |
| Cipargamin 50 mg QD 3 days | 19 | 6 (32) | 6 (32) |
| Total | 133 | 34 (26) | 22 (17) |
Abbreviations: QD, daily; PfATP4, Plasmodium falciparum ATPase 4; SD, single dose.