Table 2. Univariable and multivariable analysis of 30-day all-cause and Clostridioides difficile–attributable mortality, Canada, 2015–2019*.

Characteristics	Univariable analysis			Multivariable analysis
	Odds ratio (95% CI)	p value		Adjusted odds ratio (95% CI)	p value
All-cause mortality
Sex
M	Referent			Referent
F	1.15 (0.91–1.45)	0.2484		1.26 (0.93–1.70)	NS
Age group, y
<65	Referent			Referent
>65	2.66 (2.00–3.53)	<0.0001		3.63 (2.45–5.39)	<0.0001
Severe CDI†	2.53 (1.90–3.36)	<0.0001		2.66 (1.90–3.73)	<0.0001
CDI case type
Community-associated	Referent			Referent
Healthcare-associated	1.65 (1.21–2.24)	0.0014		1.83 (1.23–2.72)	0.0028
RT027 vs. non-RT027	1.48 (1.04–2.10)	0.0289		1.10 (0.74–1.63)	NS
RT106 vs. non-RT106	1.09 (0.73–1.63)	0.6804		NA
CDI-attributable mortality
Sex
M	Referent			Referent
F	1.22 (0.79–1.87)	0.3776		1.33 (0.81–1.19)	NS
Age group, y
<65	Referent			Referent
>65	3.28 (1.84–5.85)	<0.0001		3.44 (1.73–6.82)	0.0004
Severe CDI†	2.40 (1.45–4.0)	0.0006		2.25 (1.28–3.94)	0.0050
CDI case type
Community-associated	Referent			Referent
Healthcare-associated	1.29 (0.76–2.22)	0.3476		1.25 (0.67–2.35)	NS
RT027 vs. non-RT027	3.17 (1.89–5.29)	<0.0001		2.85 (1.64–5.00)	0.0002
RT106 vs. non-RT106	0.95 (0.45–2.00)	0.8830		NA

*Bold text indicates statistical significance. CDI, Clostridioides difficile infection; NA, not applicable; NS, not significant; RT, ribotype. †Severe CDI defined as albumin level <30 g/L, leukocyte count >15 × 10⁹ cells/L, or both.