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. 2022 May 24;2022:3959390. doi: 10.1155/2022/3959390

Figure 2.

Figure 2

The crosstalk between Nrf2 and NF-κB signaling pathway (created with BioRender.com). (a) Nrf2-dependent antioxidant genes could block TLR and TNF-dependent signaling. (b) Nrf2 and NQO1 inhibit the priming step of NLRP3, and suppress caspase-1 cleavage and IL-1β generation. (c) Keap1 could ubiquitinate IKK and be targeted by 15d-PGJ2. (d) Nrf2 and NF-κB could compete to combine with CBP. Nrf2: nuclear factor erythroid-2 related factor 2; NF-κB: nuclear factor-κB; HO-1: heme oxygenase-1; NQO1: NAD(P)H quinone dehydrogenase-1; TLR: toll-like receptors; TNFR: tumor necrosis factor receptor; NLRP3: nucleotide-binding oligomerization domain-like receptor protein 3; IL-1β: interleukin-1β; Keap1: kelch-like ECH-associated protein 1; IKK: inhibitors of NF-κB kinase; CBP: cAMP-response-element-binding protein-binding protein.