Table 1.

Modulation of different ncRNAs by quercetin and its derivatives in cancer.

Biological process	Quercetin type	Target ncRNA	Cancer type	Expression	Mechanism	Reference
Anticarcinogenesis	Methoxylated quercetin glycoside	miR-15a, miR-16	Hepatocellular carcinoma	↑	Suppress the expression of oncogenes (e.g., Bcl-2, CCND1, and Mcl-1)	[105]
Proapoptosis	Quercetin	miR-34a	Hepatocellular carcinoma	↑	Inactivate the p53 signaling pathway by targeting SIRT1	[106]
Anticarcinogenesis	Quercetin	miR-22	Oral squamous cell carcinoma	↑	Impede the Wnt1/β-catenin signaling cascade	[24]
Antiproliferation	Quercetin	let-7c	Pancreatic cancer	↑	Upregulate Numbl and downregulate Notch	[107]
Antiproliferation	Quercetin	miR-1275	Hepatocellular carcinoma	↑	Suppress the expression of IGF2BP1 and IGF2BP3	[108]
Proapoptosis	Quercetin	miR-197	Meningioma	↑	Suppress the expression of IGFBP5	[23]
Proapoptosis, anti-invasion, and antimetastasis	Quercetin	miR-146a	Breast cancer	↑	Upregulate Bax and cleaved caspase-3; downregulate EGFR	[109]
Proapoptosis	Quercetin	miR-15a, miR-16	B-chronic lymphocytic leukemia	↑	Suppress the expression of Bcl-2	[110]
Proapoptosis	Quercetin	miR-145	Ovarian cancer	↑	Induce the activation of caspase-3	[111]
Antimigration, anti-invasion	Quercetin, hyperoside	miR-21	Prostate cancer	↓	Suppress the expression of PDCD4	[112]
Proapoptosis	Quercetin	miR-125b-2-3p, miR-320b, miR-320c, miR-320d, and miR-338-3p	Colon cancer	↑	Unknown	[113]
Antiproliferation, antimigration	Quercetin	miR-16	Lung adenocarcinoma	↑	Suppress the expression of claudin-2	[114]
Antimigration, anti-invasion	Quercetin	miR-16	Oral cancer	↑	Suppress the expression of HOXA10	[115]
Chemosensitization	Quercetin	miR-217	Osteosarcoma	↑	Suppress the expression of KRAS	[116]
Chemosensitization	Rhamnetin	miR-148a	Hepatocellular carcinoma	↑	Suppress the expression of PXR and drug resistance-associated genes (e.g., cyp3a4 and mdr-1)	[117]
Antiproliferation, proapoptosis	Hyperoside	CCAT1	Non-small-cell lung cancer	↓	Suppress the expression of Foxo1	[118]
Antimigration, anti-invasion	Quercetin	MALAT1	Prostate cancer	↓	Upregulate N-cadherin and phosphorylated Akt; downregulate E-cadherin	[21]
Proapoptosis	Quercetin	ENST00000313807, ENST00000449307	Colon cancer	↓	Enhance the expression of LRG1 by targeting miR-5096	[113]
Antiproliferation	Quercetin	MALAT1, hsa_circ_001859, hsa_circ_0089761, MYO10, and ARPP19	Cervical cancer	—	Alter the expression of JUN, AR, and EGFR	[119]