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. 2022 Apr 1;27(6):2821–2832. doi: 10.1038/s41380-022-01518-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The efficiency of the 4^th enzymatic turnover of APP_C99 quantified by the Aβ (37 + 38 + 40) / (42 + 43) ratio. Data are represented as mean ± SD, N ≥ 4 independent experiments. One-way ANOVA followed by Dunnett’s post-hoc test with comparison to wild type was used to determine statistical significance (p < 0.05); ****p < 0.0001, (F(DFn, DFd): F (27, 185) = 200.6); (B) Correlative analysis between AAO and Aβ (37 + 38 + 40) / (42 + 43) ratio (efficiency of the 4^th catalytic turn-over) (Y = 1.996*X - 37.8). The 95% confidence interval (light grey surface) and correlation coefficient (R²) are shown. The error bars present SD and range for Aβ ratio and AAO, respectively.