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. 2022 May 23;21(6):710–720. doi: 10.1038/s41563-022-01251-z

Extended Data Fig. 5. Lower doses of LND-CDN exhibited similar transient toxicity but substantially reduced efficacy.

Extended Data Fig. 5

Groups of C57Bl/6 mice (n = 10 animals/group) were inoculated with 3 × 105 MC38 tumour cells s.c. in the flank on day 0, then treated on day 7 with a single dose of 5 nmol LND-CDN, a single dose of 2.5 nmol LND-CDN, two doses at days 7 and 14 of 2.5 nmol LND-CDN, or saline control. Shown are tumour growth curves (mean ± s.e.m.) (a), overall survival (b), and weight loss (mean ± s.e.m.) (c) of animals over time.