Table 1.
Difference between the antimicrobial non-susceptible profiles of CC271 and CC983 of serotype 19F S. pneumoniae
| Antibiotic | Parameter | CC983 (n = 46) | CC271 (n = 58) | P |
|---|---|---|---|---|
| Penicillin | NS% | 0 | 8·6% | 0·03 |
| MIC50 (mg/l) | 0·094 | 1 | — | |
| MIC90 (mg/l) | 0·125 | 2 | — | |
| MICrange (mg/l) | 0·008–0·125 | 0·19–3 | — | |
| Amoxicillin-clavulanic acid | NS% | 0 | 12·1% | 0·00 |
| MIC50 (mg/l) | 0·016 | 1 | — | |
| MIC90 (mg/l) | 0·023 | 4 | — | |
| MICrange (mg/l) | 0·008–0·047 | 0·008–4 | — | |
| Ceftriaxone | NS% | 0 | 96·4% | 0·00 |
| MIC50 (mg/l) | 0·25 | 32 | — | |
| MIC90 (mg/l) | 0·75 | 256 | — | |
| MICrange (mg/l) | 0·094–1 | 0·5–512 | — | |
| Cefaclor | NS% | 0 | 29·3% | 0·00 |
| MIC50 (mg/l) | 0·032 | 1 | — | |
| MIC90 (mg/l) | 0·064 | 2 | — | |
| MICrange (mg/l) | 0·001–0·094 | 0·25–4 | — | |
| Cefuroxime | NS% | 0 | 89·7% | 0·00 |
| MIC50 (mg/l) | 0·094 | 3 | — | |
| MIC90 (mg/l) | 0·19 | 6 | — | |
| MICrange (mg/l) | 0·047–0·25 | 0·5–12 | — | |
| Erythromycin | NS% | 100% | 100% | 1 |
| MIC50 (mg/l) | 256 | 256 | — | |
| MIC90 (mg/l) | 256 | 256 | — | |
| MICrange (mg/l) | 24–512 | 2–512 | — | |
| Imipenem | NS% | 0 | 87·9% | 0·00 |
| MIC50 (mg/l) | 0·047 | 0·25 | — | |
| MIC90 (mg/l) | 0·064 | 0·25 | — | |
| MICrange (mg/l) | 0·023–0·064 | 0·023–0·5 | — | |
| Vancomycin | NS% | 0% | 0% | 1 |
| MIC50 (mg/l) | 0·38 | 0·5 | — | |
| MIC90 (mg/l) | 0·5 | 0·75 | — | |
| MICrange (mg/l) | 0·125–0·5 | 0·25–0·75 | — | |
| Levofloxacin | NS% | 0 | 0 | 1 |
| MIC50 (mg/l) | 0·75 | 0·75 | — | |
| MIC90 (mg/l) | 1 | 1 | — | |
| MICrange (mg/l) | 0·5–1 | 0·38–1·5 | — | |
| Chloramphenicol | NS% | 39·1% | 3·4% | 0·00 |
| MIC50 (mg/l) | — | — | — | |
| MIC90 (mg/l) | — | — | — | |
| MICrange (mg/l) | — | — | — | |
| Tetracycline | NS% | 95·7% | 98·3% | 1 |
| MIC50 (mg/l) | — | — | — | |
| MIC90 (mg/l) | — | — | — | |
| MICrange (mg/l) | — | — | — | |
| Sulfamethoxazole–trimethoprim | NS% | 95·7% | 93·1% | 1 |
| MIC50 (mg/l) | — | — | — | |
| MIC90 (mg/l) | — | — | — | |
| MICrange (mg/l) | — | — | — |
NS%, Percentage of non-susceptibility; MIC50, 50% minimum inhibitory concentration; MIC90, 90% minimum inhibitory concentration; MICrange, range of minimum inhibitory concentration.