Table 5.

Twelve-step desensitization protocol for carboplatin total dose 600 mg

	Volume (mL)	Concentration (mg/mL)	Amount infused (mL)	Total mg per bag
Solution 1	250	0.024	9.38	6
Solution 2	250	0.24	18.75	60
Solution 3	250	2.38	250	595.27
Step	Solution	Rate (mL/h)	Time (min)	Volume infused per step (mL)	Dose per step (mg)	Cumulative dose (mg)
1	1	2.5	15	0.63	0.015	0.015
2	1	5	15	1.25	0.03	0.045
3	1	10	15	2.5	0.06	0.11
4	1	20	15	5	0.12	0.23
5	2	5	15	1.25	0.3	0.53
6	2	10	15	2.5	0.6	1.13
7	2	20	15	5	1.2	2.33
8	2	40	15	10	2.4	4.73
9	3	10	15	2.5	5.95	10.68
10	3	20	15	5	11.91	22.58
11	3	40	15	10	23.81	46.39
12	3	80	174.38	232.5	553.61	600
Total time (min) = 339.38 = 5.66 h

Solution 1 is a 100-fold dilution of the final target concentration; solution 2 is a tenfold dilution of the final target concentration, and the concentration of solution 3 is calculated by subtracting the cumulative dose administered in steps 1–8 from the total target dose and dividing by the bag volume. Values shown are rounded to the nearest 2 decimal places