Table 6.

Eight-step desensitization protocol for carboplatin total dose 600 mg

	Volume (mL)	Concentration (mg/mL)	Amount infused (mL)	Total mg per bag
Solution 1	250	0.24	18.75	60
Solution 2	250	2.38	250	595.5
Step	Solution	Rate (mL/h)	Time (min)	Volume infused per step (mL)	Dose per step (mg)	Cumulative dose (mg)
1	1	5	15	1.25	0.3	0.3
2	1	10	15	2.5	0.6	0.9
3	1	20	15	5	1.2	2.1
4	1	40	15	10	2.4	4.5
5	2	10	15	2.5	5.96	10.46
6	2	20	15	5	11.91	22.37
7	2	40	15	10	23.82	46.19
8	2	80	174.38	232.5	553.81	600
Total time (min) = 279.38 = 4.66 h

Solution 1 is a tenfold dilution of the final target concentration. The concentration of solution 2 is calculated by subtracting the cumulative dose administered in steps 1–4 from the total target dose and dividing by the bag volume. Values shown are rounded to the nearest 2 decimal places