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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Curr Opin Genet Dev. 2022 Apr 12;74:101901. doi: 10.1016/j.gde.2022.101901

Figure 1. IDR/chromatin-associating fusion proteins in cancer.

Figure 1.

A. The proposed mechanism of action of IDR/chromatin-associating fusion proteins in cancer. Fusion proteins bind chromatin at enhancers and gene promoters and recruit bound loci into phase separation dependent condensates activating oncogenic transcriptional profiles. B. A list of IDR/DNA-binding fusion proteins frequently found in cancer that have been described to phase separate in the nucleus. *In vitro/in vivo assays for coalescence, fusion/fission, concentration dependency. FRAP: Fluorescence recovery after photobleaching.