. Author manuscript; available in PMC: 2023 Jun 1.

Published in final edited form as: Curr Opin Genet Dev. 2022 Apr 12;74:101901. doi: 10.1016/j.gde.2022.101901

Table 1. Other nuclear phase-separating fusion proteins in cancer.

A list of phase-separating fusion proteins frequently found in cancer that combine an IDR/chromatin-associating-containing proteins and a fusion partner that alters the distribution and/or role of the first component. *In vitro/in vivo assays for coalescence, fusion/fission, concentration dependency. FRAP: Fluorescence recovery after photobleaching.

Fusion proteins	Type of cancer	Evidence for phase separation
		Condensates observed	General^*	FRAP	1,6-Hexanediol disruption	IDR mutations	Alters 3D chromatin
BRD4-NUT	Squamous cell carcinoma, midline carcinoma	Yes[48–50]	-	-	-	-	Yes[48]
SS18-SSX1/2	Synovial sarcoma	Yes[53,55]	Yes [53]	Yes [53]	Yes [53]	Yes [53]	-

In vitro/in vivo assays for coalescence, fusion/fission, concentration dependency