Fig. 1. Omega-3 epoxides in murine lungs are reduced with exposure of hypoxia.

a, b Omega-3 fatty acid metabolites in LC-MS/MS based-lipidomics of the lungs of WT mice exposed to normoxia or hypoxia (10% O₂) for 4, 14, and 28 days. a EPA metabolites, b DHA metabolites. Z-score was calculated from the average value of each group (n = 3) and shown as heatmap. c The contents of ω-3 epoxides (17,18-EpETE and 19,20-EpDPE) and their dihydrodiols (17,18-diHETE and 19,20-diHDoPE) assessed by LC-MS/MS based-lipidomics of lungs of WT mice subjected to normoxia or hypoxia for 4, 14, and 28 days (n = 3). Data are mean ± SEM. P values were determined by one-way ANOVA with Dunnett’s post hoc test.