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. 2022 May 31;13(5):511. doi: 10.1038/s41419-022-04910-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A One of the top 3 differential genes between the GSDMD positive macrophage and GSDMD-negative macrophage was CXCL10 by scRNA-seq. B Bubble heatmap showing the mean attraction strength for selected ligand-receptor pairs between the GSDMD-positive/negative macrophage with Stromal cell. Dot size indicates P-value generated by permutation test, colored by attraction strength levels. C Scheme. D Levels of mRNA encoding Fibronectin, collagen I1α by RT-qPCR. E Representative overall photo and photomicrographs of PAS staining. F Immunofluorescence. Representative photomicrographs for immunofluorescence labeled α-SMA (red) and FN (green). Corresponding graphs indicate the expression of α-SMA (red) and FN (green). Data are presented as the mean ± SEM, n = 5/group, **P < 0.01, ***P < 0.001; Scale bar: 100 μm.