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. 2022 May 31;5:522. doi: 10.1038/s42003-022-03465-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a TetX-related proteins are divided into three classes: TetX-A (green), TetX-B (yellow), and TetX-C (orange). Phylogeny is inferred by using the maximum-likelihood method and Flu +G + I model. A discrete Gamma distribution approach was used to depict the difference in evolutionary rate among the sites [4 categories (Gamma shape parameter = 0.609)]. This analysis involved 128 amino acid sequences. Different species hits the protein sequences organized in the phylum level. Bacteroidetes, Proteobacteria, Firmicutes, Spirochetes, Bacteroidetes plus Proteobacteria, and unclassified organisms are shown in blue, pink, light purple, and gray, respectively. Evolutionary analyses were conducted in online PlyML 3.0. The tree was visualized using iTOL (ITEREACTIVE TREE OF LIFE). b Phylogenetic analysis of the amino acid sequences of the reported TetX variants. The maximum-likelihood tree was inferred using MEGA X³⁵. The tree is drawn to scale, with branch lengths measured in the number of substitutions per site. c Reported TetX variants are distributed in TetX-A class, TetX-B class, and TetX-C class with specific substitutions.