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. 2022 May 31;13(5):510. doi: 10.1038/s41419-022-04946-y

Fig. 7. Rate of Jo2-induced hepatocyte cell death in vitro.

Fig. 7

Primary Bcl-3Hep and WT hepatocytes were treated ex vivo with Jo2 (50 ng/mL). Pan caspase inhibitor zVAD (50 µM), JNK inhibitor SP600125 (100 µM), or IKK inhibitor BAY-11-7082 (10 µM), where ever indicated, were added 1 h before Jo2-treatment. After 12 and 18 h cell survival was assessed by MTT assay. Untreated hepatocytes were used as baseline controls. Numerical data in mean ± SEM of two independent experiments performed at least in duplicate readings. **p < 0.01, ***p < 0.001 for WT vs. Bcl-3Hep and $p < 0.05, $$p < 0.01 for untreated vs. treated hepatocytes according to an unpaired, two-tailed Student’s t-test.