Table 1.
Hepatic gene expression of (A) anti-apoptotic proteins and (B) NF-κB subunits in Bcl-3Hep and WT mice at 4 h post d-GalN/LPS challenge and in control animals.
| (A) | ||||
|---|---|---|---|---|
| WT + PBS | WT + d-GalN/LPS | Bcl-3Hep + PBS | Bcl-3Hep + d-GalN/LPS | |
| BCL-2 | 1.00 ± 0.21 | 41.46 ± 8.58 ($) | 0.88 ± 0.08 | 23.39 ± 1.72 ($$) |
| BCL-XL | 1.00 ± 0.12 | 0.59 ± 0.03 ($) | 0.57 ± 0.02 | 0.95 ± 0.43 |
| cIAP1 | 1.00 ± 0.11 | 4.10 ± 0.48 ($) | 0.83 ± 0.10 | 3.00 ± 0.35 ($$) |
| c-FLIPL | 1.00 ± 0.07 | 0.89 ± 0.05 | 0.92 ± 0.04 | 0.81 ± 0.03 |
| c-FLIPS | 1.00 ± 0.06 | 0.96 ± 0.06 | 0.78 ± 0.05 | 1.06 ± 0.06 |
| MCL-1 | 1.00 ± 0.04 | 0.60 ± 0.08 | 1.17 ± 0.24 | 0.66 ± 0.12 |
| A20 | 1.00 ± 0.06 | 5.41 ± 0.80 ($) | 0.76 ± 0.06 | 4.29 ± 0.10 ($) |
| XIAP | 1.00 ± 0.04 | 0.81 ± 0.03 ($) | 0.95 ± 0.1 | 0.74 ± 0.06 |
| (B) | ||||
| p50/p105 | 1.00 ± 0.09 | 2.44 ± 0.25 ($) | 0.83 ± 0.05 | 1.90 ± 0.1 ($$) |
| c-Rel (Rel) | 1.00 ± 0.17 | 1.03 ± 0.13 | 0.77 ± 0.06 | 1.70 ± 0.55 ($) |
| p65 (RelA) | 1.00 ± 0.25 | 0.39 ± 0.13 | 0.19 ± 0.02 (*) | 0.53 ± 0.08 ($) |
| RelB | 1.00 ± 0.08 | 2.84 ± 0.53 ($) | 0.99 ± 0.13 | 2.62 ± 0.02 ($) |
Data in (A) and (B) are shown as mean of n = 3-6 mice/group ± SEM. *p < 0.05 for WT vs. Bcl-3Hep and $p < 0.05, $$p < 0.01 for PBS vs. d-GalN/LPS using Mann–Whitney U test (A and B). There was no statistically significant difference between WT + d-GalN/LPS vs. Bcl-3Hep + d-GalN/LPS in respect of the parameters.