Figure 1.

Intraperitoneal injection of luciferase mRNA demonstrates different tissue exposure patterns depending on lipid nanoparticle formulation

(A and B) Comparative (A) and quantitative (B) bioluminescent imaging of P12 mice intraperitoneally administered LNP A or LNP B formulated with firefly luciferase mRNA demonstrates greater hepatic luciferase protein expression with LNP B; greater abdominal wall injection site expression was detected with LNP A. Low to modest LNP exposure was detected in other organs; such low levels cannot rule out that expression is from contaminated blood cell expression. Data are represented as mean ± SEM (n = 5 per group) (pseudocolor scale: red = highest, purple = lowest). LNP, lipid nanoparticle.