Figure 4.

Administration of LNP-formulated ARG1 results in functional hepatic arginase activity

Representative images in (A) demonstrate bands of arginase 1 protein in wild-type liver and primarily in Arg1^−/− hepatocytes where LNP B-formulated ARG1 mRNA was administered. Functional arginase expression (B) is, while reduced compared with wild type (black bar), reestablished in LNP-administered mice, with the LNP B (blue bar) greater than LNP A formulation (green bar) (n = 6 per group). ARG1, arginase 1; Arg1, arginase 1; LNP, lipid nanoparticle. Data are represented as mean ± SD.