Figure 5.

Elevated plasma ammonia and altered urea-cycle-related amino acids are improved with LNP-mediated mRNA delivery

The urea-cycle-related plasma amino acids of (A) alanine, (B) aspartate, (C) arginine, (D) citrulline, (E) glutamate, and (F) glutamine are generally improved (LNP A formulation Arg1^−/−) or completely corrected (LNP B formulation Arg1^−/−; p ≥ 0.796) with mRNA therapy depending on the LNP formulation; ornithine (G), the exception, is reduced with the LNP B formulation. Plasma ammonia (H) is improved with both formulations, albeit better with the LNP B formulation. (N = 6–7 per group). Arg1, arginase 1; mRNA, messenger ribonucleic acid; LNP, lipid nanoparticle. Data are represented as mean ± SD.