Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 21;61(6):2472–2482. doi: 10.1093/rheumatology/keab781

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Fig. 1 — (Immuno-)histological analysis of parotid gland tissue from pSS patients

Parotid gland biopsies from pSS patients showing (A) a periductal focus on H&E staining with a centrally located lymphoepithelial lesion. (B) High-resolution image of the same lymphoepithelial lesion showing hyperplastic epithelium with intra-epithelial lymphocytes. (C) The presence of a germinal centre, as shown by a cluster of five or more Bcl6⁺ cells. (D) Dual staining for IgA (red) and IgG (brown) plasma cells showing an influx of IgG⁺ plasma cells. (E) CD45 staining of parotid gland tissue. (F) Digital image analysis of the relative area of CD45⁺ infiltrate by using QuPath. (G) Parotid gland tissue stained with a modified Masson stain in which dense connective tissue is coloured blue. (H) Digital image analysis of the modified Masson staining by using QuPath, in which red represents fibrotic tissue, yellow represents fat cells and green represents glandular parenchyma.