Figure 1.

Overview of the experimental design and data analysis

Extracellular vesicles (EVs) are isolated from cell culture media and serum of patient with prostate cancer (PCa). Subsequently, the proteo-transcriptome of cells and their EVs are characterized. Detailed information regarding the proteomic and transcriptomic datasets used in this study is provided in the respective tables. In addition to in-house data generation, external data are curated from following studies (Hurwitz et al., 2016, Diaz-Varela et al., 2018, Hinger et al., 2018, Wei et al., 2017 and Herrera et al., 2018).