Figure 3.

EVs enrich for unique protein signatures that are different from their cancer cell of origin

(A) Comparative analyses of proteomic data of EVs and their cancer cell or origin. Subcellular location of donor cancer cell proteome and EVs show that EVs enrich cytoplasmic, extracellular, and endosomal proteins.

(B) Gene Ontology enrichment of proteins in cells and EVs. EVs enrich endosomal, cytoplasmic, and ribosomal proteins. Significance is demonstrated with following annotation: ns – not significant, ∗ - P<= 0.05, ∗∗ - P<=0.01. FDR are the adjusted p values using false discovery rate correction for multiple testing.