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. 2022 May 18;25(6):104414. doi: 10.1016/j.isci.2022.104414

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Proteo-transcriptomic analyses of EVs from serum of patient with prostate cancer reveal distinct RNA and protein signatures

(A) TEM image of UC isolated EVs.

(B) A size and concentration analyses of serum EVs show distribution of vesicles (50–150 nm).

(C) Immunofluorescence co-localization analyses of serum EVs confirmed the presence of canonical tetraspanin CD9 on vesicle surface. Optical image of immunofluorescence co-localization analyses shows EVs specificity to CD9 but not to mouse IgG.

(D) Top 30 proteins detected in serum EVs.

(E) Top 30 RNA detected in serum EVs.