Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 17;15:888523. doi: 10.3389/fnmol.2022.888523

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Sun, Ji, Liang, Ming, Chen, Zhang, Zhou, Shen and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic diagram of the association of protein acetylation with sciatic nerve development, injury, and regeneration. Under the regulation of numerous acetylation regulators, such as Hdac1/2 and Kat2b, changes in protein acetylation link sciatic nerve development, injury, and regeneration. During development, the total acetylation level is increased, driven by Hdac1/2 downregulation and Kat2b upregulation. During injury, the total acetylation level is decreased, driven by Hdac1/2 upregulation and Kat2b downregulation. During regeneration, the total acetylation level is increased, driven by Hdac1/2 downregulation and Kat2b upregulation. The regular changes in acetylation may affect cell cycle-related pathways, resulting in similar physiological changes such as myelination and lamellar thickening during sciatic nerve development and regeneration and inverse physiological changes such as myelin degradation during injury.