Table 1.
Characteristics of study population at baseline from ESTHER study.
| Characteristics | Subset I (N=727) | Subset II (N=1003) | Subset III (N=910) | Subset IV (N=412) |
Entire ESTHER cohort (N=9940) | |
|---|---|---|---|---|---|---|
| Controls (N=205) | Cases (N=207) | |||||
| Age (years; mean ± SD) | 61·6±6·5 | 62·0±6·7 | 61·9±6·5 | 62·5±6·4 | 63·2±6·0 | 62·1±6·6 |
| Sex (N/%) | ||||||
| Men | 320 (44·0) | 435 (43·4) | 448 (49·2) | 88 (42·9) | 132 (63·8) | 4478 (45·0) |
| Women | 407 (56·0) | 568 (56·6) | 462 (50·8) | 117 (57·0) | 75 (36·2) | 5462 (55·0) |
| Educational levels (N/%)a | ||||||
| Low (≤9 years) | 519 (73·5) | 748 (76·3) | 672 (73·9) | 149 (74·5) | 162 (78·3) | 7235 (74·7) |
| Intermediate (10-11 years) | 112 (15·9) | 131 (13·4) | 141 (15·5) | 34 (17·0) | 23 (11·1) | 1372 (14·2) |
| High (≥12 years) | 75 (10·6) | 101 (10·3) | 97 (10·7) | 17 (8·5) | 19 (9·2) | 1081 (11·2) |
| Body mass index (N/%)b | ||||||
| Normal weight (<25·0 kg/m2) | 188 (25·9) | 269 (26·9) | 231 (25·4) | 64 (31·2) | 49 (23·7) | 2724 (27·5) |
| Overweight (25·0-<30·0 kg/m2) | 346 (47·7) | 475 (47·5) | 437 (48) | 100 (48·8) | 97 (46·9) | 4675 (47·1) |
| Obesity (≥30·0 kg/m2) | 192 (26·5) | 256 (25·6) | 242 (26·6) | 41 (20·0) | 61 (29·5) | 2525 (25·4) |
| Smoking status (N/%)c | ||||||
| Never smoker | 354 (48·7) | 520 (51·8) | 445 (48·9) | 96 (49·5) | 63 (30·4) | 4832 (50·0) |
| Former smoker | 241 (33·2) | 318 (31·7) | 295 (32·4) | 61 (31·4) | 82 (39·6) | 3185 (33·0) |
| Current smoker | 132 (18·2) | 165 (16·5) | 170 (18·7) | 37 (19·1) | 60 (29·0) | 1649 (17·0) |
| Diabetesd | ||||||
| Yes | 608 (85) | 866 (87·4) | 769 (84·5) | 175 (85·8) | 169 (81·6) | 8230 (85·0) |
| No | 107 (15) | 125 (12·6) | 141 (15·5) | 29 (14·2) | 35 (16·9) | 1455 (15·0) |
| Alcohol consumption (grams per day; mean ± SD) | 9·3±12·8 | 9·8±13 | 9·7±13·7 | 10·4±14·1 | 12·2±17·7 | 9·8±14·0 |
Abbreviations: SD, standard deviation; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs.
a
Data missing for 21, 23, 8, and 252 participants in subset I, II, IV, and all study population in ESTHER.
b
Data missing for 1, 3, and 16 participants in subset I, II, and all study population in ESTHER.
c
Data missing for 13 and 274 participants in subset IV and all study population in ESTHER.
d
Data missing for 12, 12, 4 and 255 participants in subset I, II, IV, and all study population in ESTHER.