Table 2.
Associations of DNAm algorithms and total and site-specific cancer risk in all subsets.
| Predictors | HR (95% CI) |
||
|---|---|---|---|
| Cases | Model 1 | Model 2a | |
| Overall incident cancera | |||
| AgeAccelPheno (per SD) | 490 | 1·05 (0·96-1·15) | 1·11 (0·92-1·34) |
| AgeAccelGrim (per SD) | 490 | 1·15 (1·05-1·26) | 1·12 (0·96-1·30) |
| MRscore-8CpGs (per SD) | 490 | 1·28 (1·07-1·52) | 1·27 (1·04-1·56) |
| Incident breast cancerb | |||
| AgeAccelPheno (per SD) | 75 | 0·73 (0·56-0·94) | 0·65 (0·49-0·86) |
| AgeAccelGrim (per SD) | 75 | 0·67 (0·48-0·93) | 0·45 (0·25-0·80) |
| MRscore-8CpGs (per SD) | 75 | 0·57 (0·38-0·87) | 0·42 (0·25-0·70) |
| Incident lung cancerb | |||
| AgeAccelPheno (per SD) | 146 | 1·53 (1·23-1·90) | 1·37 (1·03-1·82) |
| AgeAccelGrim (per SD) | 146 | 2·62 (2·21-3·11) | 1·74 (1·11-2·73) |
| MRscore-8CpGs (per SD) | 146 | 2·87 (2·36-3·48) | 2·06 (1·39-3·06) |
| Incident prostate cancerb | |||
| AgeAccelPheno (per SD) | 114 | 1·02 (0·77-1·36) | 0·97 (0·77-1·24) |
| AgeAccelGrim (per SD) | 114 | 0·89 (0·72-1·08) | 0·89 (0·69-1·15) |
| MRscore-8CpGs (per SD) | 114 | 0·90 (0·64-1·27) | 1·00 (0·73-1·37) |
| Incident colorectal cancerb | |||
| AgeAccelPheno (per SD) | 155 | 1·01 (0·80-1·27) | 1·24 (0·86-1·78) |
| AgeAccelGrim (per SD) | 155 | 0·83 (0·60-1·15) | 1·09 (0·81-1·45) |
| MRscore-8CpGs (per SD) | 155 | 0·73 (0·59-0·90) | 1·03 (0·70-1·50) |
Abbreviations: DNAm, DNA methylation; HR, hazard ratio; CI, confidence interval; SD, standard deviation; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs.
Meta-analysis of subset I, II, and III.
Meta-analysis of all subsets. In subset IV, only targeted cancer cases and controls were included into the analyses.
Model 1, adjusted for age, sex, leukocyte composition, and batch.
Model 2, similar as model 1, additionally adjusted for educational level, smoking status (never smoker, former smoker, current smoker), alcohol consumption (grams per day), body mass index (kg/m2), and diabetes. Models for incident breast cancer were additionally adjusted for menopausal status and postmenopausal hormone use.