Table 3.
Dose-response relationship between the DNAm scores and breast cancer risk in subset I, II, and III.
| Predictors | Quartiles | Person-years | Cases | HR (95% CI)a | P-trend |
|---|---|---|---|---|---|
| AgeAccelPheno |
Q1 | 5987·4 | 27 | 1·00 (Ref·) | 0·759 |
| Q2 | 5185·7 | 15 | 0·83 (0·17-3·98) | ||
| Q3 | 4980·9 | 18 | 0·79 (0·22-2·81) | ||
| Q4 | 4398·6 | 15 | 0·48 (0·22-1·04) | ||
| AgeAccelGrim |
Q1 | 8168·7 | 35 | 1·00 (Ref·) | 0·320 |
| Q2 | 6061·8 | 18 | 0·36 (0·10-1·33) | ||
| Q3 | 3828·0 | 15 | 0·58 (0·27-1·25) | ||
| Q4 | 2494·1 | 7 | 0·12 (0·03-0·47) | ||
| MRscore-8CpGs | Q1 | 7058·5 | 28 | 1·00 (Ref·) | 0·006 |
| Q2 | 5820·7 | 25 | 0·80 (0·19-3·34) | ||
| Q3 | 4645·3 | 15 | 0·55 (0·15-1·92) | ||
| Q4 | 3028·1 | 7 | 0·16 (0·04-0·74) | ||
Abbreviations: DNAm, DNA methylation; HR, hazard ratio; CI, confidence interval; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs.
a
Models adjusted for age, leukocyte composition, batch, educational level, smoking status (never smoker, former smoker, current smoker), alcohol consumption (grams per day), body mass index (kg/m2), diabetes, menopausal status, and postmenopausal hormone use.