Table 4.
Dose-response relationship between the DNAm scores and lung cancer risk in all subsets.
| Predictorsa | Quartiles | Person-years | Cases | HR (95% CI)b | P-trend |
|---|---|---|---|---|---|
| AgeAccelPheno |
Q1 | 11068·3 | 22 | 1·00 (Ref·) | 0·033 |
| Q2 | 10937·8 | 25 | 1·36 (0·66-2·82) | ||
| Q3 | 11256·6 | 35 | 1·29 (0·56-2·99) | ||
| Q4 | 11448·9 | 64 | 1·95 (1·11-3·41) | ||
| AgeAccelGrim |
Q1 | 11589·0 | 10 | 1·00 (Ref·) | 0·003 |
| Q2 | 10926·3 | 15 | 1·76 (0·13-23·54) | ||
| Q3 | 11674·8 | 25 | 3·35 (0·58-19·26) | ||
| Q4 | 10521·5 | 96 | 5·83 (0·54-63·55) | ||
| MRscore-8CpGs | Q1 | 10927·1 | 11 | 1·00 (Ref·) | 0·003 |
| Q2 | 10925·8 | 16 | 0·72 (0·25-2·11) | ||
| Q3 | 11268·1 | 31 | 1·59 (0·27-9·41) | ||
| Q4 | 11590·6 | 88 | 4·15 (1·01-17·09) | ||
Abbreviations: DNAm, DNA methylation; HR, hazard ratio; CI, confidence interval; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs.
a
In subset IV, only lung cancer cases and controls were included into the analyses.
b
Models adjusted for age, sex, leukocyte composition, batch, educational level, smoking status (never smoker, former smoker, current smoker), alcohol consumption (grams per day), body mass index (kg/m2), and diabetes.