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. 2022 May 18;12:844527. doi: 10.3389/fonc.2022.844527

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Copyright © 2022 Du, Qiu, Lu, Zhu, Kong, Xu, Zhang, Tang, Chen, Li, Li, He, Gu, Wang, Qiu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of mutated genes associated with prognosis. (A, B) TP35 and KRAS mutations were significantly correlated to ORR of AG chemotherapy. The ORR of TP53 mutant patients is 46.3%, while the ORR of TP53 wild type patients is 18.2%.The ORR of KRAS mutant patients is 43.8%, while the ORR of KRAS wild type patients is 0%. (C, D) EPHA7, RNF43, and HMGA2 mutations were significantly correlated to the DCR of AG chemotherapy. The DCR of EPHA7 mutant patients is 0%, while the DCR of EPHA7 wild type patients is 79.1%.