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. 2022 May 18;12:837408. doi: 10.3389/fonc.2022.837408

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Copyright © 2022 Kiriacos, Khedr, Tadros and Youness

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anticancer activities of EGCG and quercetin. Epigallocatechin-3-gallate (EGCG) and quercetin modulate several canonical oncological pathways such as Wnt/β-catenin and JAK/STAT pathways. Also, they modulate the expression of several anti-apoptotic proteins such as BCL2, tumor suppressor proteins such as TP53, and oncogenic drivers such as VEGF. Both active ingredients have proven to be effective in halting the malignant transformation process in several types of cancers such as breast, lung, liver, and colorectal cancers.