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. 2022 May 18;13:876321. doi: 10.3389/fimmu.2022.876321

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Copyright © 2022 Magoulopoulou, Qian, Pediatama Setiabudiawan, Marco Salas, Yokota, Rottenberg, Nilsson and Carow

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune environments of Mycobacterium tuberculosis bacteria. Localization of immune transcripts in tuberculous lung granulomas. (A) Fixed lung tissue sections of C57BL/6 and C3HeB/FeJ mice at the indicated weeks post Mtb infection (wpi) were analyzed by ISS and stained for DAPI, Auramine–Rhodamine T (AR), and hematoxylin–eosin (HE). ISS signals for indicated transcripts were plotted on AR-stained image as background. One representative image out of the three sections per condition is displayed. Scale bar: 1,000 μm. (B) Image of AR staining of C57BL/6 lung section 12 wpi is displayed with a scale bar of 1,000 μm. Rectangular regions for zoom-ins are indicated. (C) Inos and Cd68 transcripts plotted on AR image (zoom-in of B). Scale bar: 200 μm. (D) Magnification of AR image in B and C is shown for visualization of single bacteria and bacterial clumps. Scale bar: 20 μm.