Graft biopsies from baboons in both groups displayed evidence of interstitial edema and fibrosis. (A) Biopsy from B5916 (Group 1) displayed (i) mild segmental thrombotic microangiopathy, (ii) diffuse moderate interstitial edema, and (iii) acute tubular injury. (B) Biopsy from B17315 (Group 1) displayed (i) diffuse moderate interstitial edema, (ii) diffuse mild interstitial fibrosis, and (iii) acute tubular injury. (C) Biopsy from B517 (Group 2) displayed diffuse mild interstitial edema and acute tubular injury. (D) Biopsy from B1417 (Group 2) displayed (i) diffuse moderate interstitial fibrosis, (ii) diffuse mild interstitial edema, and (iii) scattered mononuclear cell infiltrates, some located within peritubular capillaries adjacent to renal tubules or located in scarred interstitium (asterisk). Hematoxylin and eosin (Size bar 50 μm)