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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Xenotransplantation. 2021 Oct 13;28(6):e12715. doi: 10.1111/xen.12715

FIGURE 3.

FIGURE 3

CMAHKO kidneys displayed an increased incidence of intimal arteritis, fibrin thrombi, and peritubular capillary inflammation. Kidneys from CMAHKO donors manifested an increased incidence of (A and B) fibrin thrombi, (C and D) vasculitis, and (E and F) peritubular capillary (PTC) inflammation. (A) Diffuse fibrin thrombi with transmural inflammation and fibrinoid necrosis is present in renal arteries. Representative image is from baboon 1417 (Group 2) H+E stain. (C) Renal artery exhibits transmural necrosis with neutrophilic infiltrate (arrows) and intraluminal periodic acid-Schiff (PAS) positive fibrin thrombus. Representative image from baboon 1417 (Group 2) PASH stain. (E) Highlighted peritubular capillaries (arrows) contain significant numbers of mononuclear cells (most likely macrophage) containing PAS-positive cytoplasmic material and adjacent immature fibrin thrombus (fibrillary, violet, PAS positive material). Representative image from baboon 8216 (Group 2) PASH stain. Non-parametric statistics was assessed by Mann–Whitney U-test; p values are presented with horizontal lines. (Size bar 50 μm)