. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Xenotransplantation. 2021 Oct 13;28(6):e12715. doi: 10.1111/xen.12715

TABLE 1.

Baboon number, donor pig phenotype, cause for termination, and evidence of immune-mediated rejection

Baboon	Donor pig phenotype	Survival (days)	Cause of death	Immune-mediated rejection
Group 1: Kidney is not from a CMAHKO pig
B9315	GTKO/CD46/CD55/TBM/EPCR/CD39	136	Infection	None
B17315	GTKO/CD46/CD55/EPCR/TFPI/CD47	237	Infection	None
B17615	GTKO/CD46/CD55/EPCR/TFPI/CD47	260	Infection	None
B10815	GTKO/CD46/TBM/EPCR/CD47/HO-1	90	Edema	AMR
B5916	GTKO/CD46/TBM	255	Rejection	AMR
Group 2: Kidney is from a CMAHKO pig
B8216	GTKO/CMAHKO/CD46/CD55/TBM/EPCR	7	Edema	AMR
B1417	TKO/CD46/CD55/TBM/EPCR/CD47/HO-1	61	Rejection	AMR/CCXR
B3917	TKO/CD46/CD55/TBM/EPCR/CD47/HO-1	0	Rejection	Suspected HAR
B15816	GTKO/CMAHKO/CD46/CD55/TBM/EPCR/CD47/HO-1	35	Rejection	Infection/AMR
B517	GTKO/CMAHKO/CD46/CD55/TBM/EPCR/CD47/HO-1	183	Trauma	AMR

Abbreviations: AMR, antibody-mediated rejection and thrombosis; CCXR, chronic cellular xenograft rejection; CD46, membrane cofactor protein; CD55, decay accelerating factor; CD47, integrin associated protein; CMAHKO, cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene-knockout; EPCR, endothelial protein C receptor; GTKO, α1,3-galactosyltransferase gene-knockout; HAR, hyperacute rejection; HO-1, human heme oxygenase-1; TBM, thrombomodulin; TFPI, tissue factor pathway inhibitor; TKO, triple-knockout.