TABLE 2.

Major histopathological findings in the kidney graft

Baboon	Histopathological findings	IMR	IMR-D/S
Group 1: Kidney is not from a CMAHKO pig
B9315	Interstitial hemorrhage, edema, glomerular/tubular necrosis, and tubular atrophy	None	N/A
B17315	Interstitial edema, fibrosis, and tubular atrophy	None	N/A
B17615	Interstitial fibrosis and tubular atrophy	None	N/A
B10815	Interstitial fibrin thrombi, dilation of Bowman’s space, and interstitial edema	AMR	Renal interstitium, multifocal/mild
B5916	Thrombotic microangiopathy, interstitial fibrin thrombi, fibrosis and edema	AMR	Glomerular: global/severe Renal interstitium: multifocal/ moderate
Group 2: Kidney is from a CMAHKO pig
B8216	Acute tubular injury, multifocal foci of interstitial vasculitis fibrin thrombi, and interstitial neutrophilic infiltrate	IRI/AMR	Renal interstitium: multifocal/mild
B1417	Hemorrhage, fibrin thrombi, tubular necrosis, fibrosis, neutrophil and mononuclear cell infiltration	AMR/CCXR	Renal interstitium: diffuse/ severe
B3917	Hemorrhage, congestion, fibrin thrombi, tubular necrosis, and neutrophilic infiltrate	HAR	Renal interstitium: diffuse/ severe
B15816	Segmental edema associated with ascending pyelonephritis, gram-negative bacteria, multifocal foci of fibrin thrombi	AMR	Renal interstitium: multifocal/mild
B517	Glomerular necrosis and dilation of Bowman’s space, interstitial edema, and fibrosis	AMR	N/A

Abbreviations: AMR, antibody-mediated thromboses and rejection; CCXR, chronic cellular xenograft rejection; HAR, hyperacute rejection; IRI, ischemia/reperfusion injury; IMR, Immune mediated rejection; D/S, distribution and severity; N/A, no evidence of immune-mediated rejection.