TABLE 4.

Summary of renal interstitial histopathologic changes

Baboon	Hem	Edema	TIF	PTC	Tublitis	TubA	TubN	Thrombi	v	ci
Group 1: Kidney is not from a CMAHKO pig
B9315	1.6	2.7	0.6	0.	0.5	2.8	1.2	0.5	0.5	1.3
B17315	0.1	1.5	0.8	0.4	0.3	1.3	0.7	0.1	0	1.4
B17615	0.0	0.3	0.9	0.5	0.3	1.1	0.5	0	0	1.1
B10815	0	1.8	0.4	1.0	0.4	2.7	0	0.2	0.1	1.9
B5916	0.1	1.5	0.3	1.0	0.2	0.8	0.4	0.6	0.5	0.5
Median	0.1	1.5	0.6	0.6	0.3	1.3	0.5	0.2	0.1	1.3
Group 2: Kidney is from a CMAHKO pig
B8216	0.5	1.2	0.2	1.2	0.6	0.6	0.6	0.8	0.6	0.3
B1417	1.8	1.5	1.6	1.2	1.1	2.5	1.3	1.3	1.2	2.5
B3917	2.0	0.2	0	1.8	0.2	0	2.0	0.5	0.7	0
B15816	0.1	1.8	1.0	1.0	0.7	2.6	0.5	0.4	0.7	0.9
B517	0.1	2.2	0.6	0.8	0.5	1.0	1.3	1.1	0.9	1.6
Median	0.5	1.5	0.6	1.2	0.6	1.0	1.3	0.5	0.92	0.9
p value	0.35	0.73	0.81	0.048	0.12	0.59	0.12	0.095	0.008	0.75

Note: Data presented are the average score for each individual animal.

Abbreviations: ci, interstitial fibrosis; edema, interstitial edema; Hem, interstitial hemorrhage; PTC, peritubular capillary inflammation; TIF, total interstitial inflammation; TubA, tubular atrophy; TubN, tubular necrosis; thrombi, renal interstitial arterial thrombi; v, vasculitis.

Median values, range and non-parametric statistical significance (Mann–Whitney U test).