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. 2022 May 18;13:818378. doi: 10.3389/fgene.2022.818378

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Copyright © 2022 Liu, Li, Li, Wen, Wang, Chen and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development and external validation of a TGFβ risk score. (A) Least absolute shrinkage and selection operator (LASSO) coefficient curves show the log (lambda) sequence of 101 prognostic genes in the TCGA-STAD cohort. (B) Cross-validation for the selection of turning parameter selection by minimum criteria in the LASSO regression model. Two dotted vertical lines using the minimum criteria were plotted at the optimal values. Four genes with the best discriminative capability were selected to develop the risk score. (C) Univariate Cox analysis of 4 predictor genes. (D) The relationship between the risk score and TGFβ clusters. (E–J) Development and validation of the risk score in TCGA-STAD, GSE15459, and GSE84437 databases respectively and the predictive accuracy of the risk score for survival.