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. 2022 May 21;15:100300. doi: 10.1016/j.mtbio.2022.100300

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 7 — Histological staining and histomorphological analysis of collagen formation in the wound after elastin-based hydrogels treatment. (A) HE staining of the wound tissue after the treatment of elastin-based hydrogels for 3, 7 and 14 days. Red arrows: blood vessel. Blue arrows: collagen. Yellow arrows: hair follicle. Scale bar: 625 μm (top), 100 μm (bottom). (B) Masson's trichrome staining of wound tissue after the treatment of elastin-based hydrogels for 3, 7 and 14 days. Scale bar: 625 μm (top), 100 μm (bottom). (C) Quantitative analysis of collagen deposition after the treatment of hydrogels for 3, 7 and 14 days. Control: Wounds without hydrogel treatment. GAE-0, GAE-50 and GAE-100: Wounds treated by GelMA hydrogels, composite hydrogels containing 50% and 100% movie elastin, respectively. N = 3. ∗P ≤ 0.05, ∗∗P ≤ 0.01, ∗∗∗P ≤ 0.001, ∗∗∗∗P ≤ 0.0001.