TABLE 4.

Multilevel analysis of variability in visual analog scale scores of mood symptoms and pain during the 12-week intensive diet intervention, adjusted for variability during the baseline period

Outcomea	H3-L6 ICC	Control ICC	Diet intervention effect on within-person variability		Between diet intervention group difference effect on mean level of symptoms
			Estimateb	P-value	Estimateb	P-value
Mood	0.30	0.29	0.20	<0.001	0.44	0.85
Energy	0.25	0.23	0.17	<0.001*	−0.30	0.88
Speed of Thoughts	0.42	0.50	0.08	0.052	2.13	0.45
Impulsivity (thoughts)	0.58	0.61	−0.07	0.09	2.13	0.53
Impulsivity (actions)	0.52	0.55	0.05	0.20	2.26	0.40
Anxiety	0.49	0.57	0.05	0.18	2.05	0.50
Irritability	0.46	0.50	0.24	<0.001*	4.25	0.23
Pain	0.77	0.64	0.46	<0.001*	0.64	0.84

Note: Phone data for the Mood and Stress survey from 12 of the 82 randomized participants could not be used in this analysis. N = 2 participants did not log any usable phone date during the Baseline period (prior to week 0 randomization visit). N = 9 participants did not log any usable phone data during the follow-up period (after week 0 randomization visit), and N = 1 participant had no usable phone data for the study due to the malfunctioning date-time mechanism on the phone that they were provided. Therefore, N = 70 participants were included in the EMA analysis utilizing Mood and Stress surveys. Note that the baseline period refers to all usable phone surveys logged between the participant’s date of enrollment and their date of randomization at week 0 visit. This table utilizes a total of 7223 phone surveys from the N = 70 participants included in this analysis.

Abbreviation: ICC, intraclass correlation coefficient.

^aExact question text provided in supplement.

^bReference level is H3-L6 diet group. Positive estimates indicate higher variability and higher mean level of symptoms in the Control diet group than in H3-L6 diet group, respectively.

^*p<0.05.