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. 2022 May 18;9:883769. doi: 10.3389/fcvm.2022.883769

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Copyright © 2022 Monosilio, Filomena, Luongo, Sannino, Cimino, Neccia, Mariani, Birtolo, Benedetti, Tonti, Pedrizzetti, Vizza, Maestrini and Agati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in hemodynamic forces distribution after Sacubitril-Valsartan. Graphic representation on a polar histogram of left ventricular hemodynamic forces (LV-HDFs) distribution in a patient: LV-HDFs distribution assessed over the entire cardiac cycle at baseline (left) and after 6 months of therapy with sacubitril-valsartan (right), showing a re-alignment of HDFs due to an improvement of longitudinal forces (apex to base, AB) over transversal ones (latero-septal, LS) and consequently a reduction of HDFs LS/AB ratio. AB, apex to base; HDFs, hemodynamic forces; LV, left ventricle; LS, latero-septal; LS/AB ratio, latero-septal over apex to base ratio.