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Central position of mTORC1 as a critical regulator of tissue repair. mTORC1 drives wound closure, blastema formation and regenerative outgrowth, including in the retina, in teleost fish and the axolotl, both considered regenerative species. In non-regenerative species, such as mammal, mTORC1 signaling is also important for wound closure, somatic stem cell proliferation, and for the initial activation of dormant stem cells in skeletal muscle to a GALERT phase.
