Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 18;10:887764. doi: 10.3389/fcell.2022.887764

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Hanna, David, Touahri, Fleming, Screaton and Schuurmans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mitochondrial dynamics. Mitochondria are dynamic structures. Mitochondrial biogenesis, or the formation of new mitochondria is triggered by transcription factors (TF), including (PPARγ) coactivator 1α (PGC-1a), estrogen-related receptor (ERR) and nuclear respiratory factors (NRFs). Mitochondrial break down, also known as mitophagy, is controlled by PTEN-induced kinase 1 (PINK), a kinase in the outer mitochondrial membrane, and Parkin, which encodes an E3-ubiquitin ligase. Mitochondria also undergo dynamic shape changes including fusion and fission. Mitochondrial fusion, which is mediated by MFN1, MFN2, and OPA1, elongates mitochondria, while mitochondrial fission or fragmentation is mediated by DRP1 and FIS1.