Table 1.
Role of mitochondrial dynamics.
| Models | Species/tissue | Phenotype | References |
|---|---|---|---|
| Cardiac-specific Mfn1 KO | Mouse heart | Small mitochondria, Heart function and size are normal | (8) |
| Mfn2 KO | Mouse cardiomyocyte | Mitochondrial dysfunction, cardiac hypertrophy | (9) |
| Mfn2 | Mouse heart | Induction of autophagosome-lysosome fusion | (10) |
| Mfn2 | HeLa cell | Mitochondrial-endoplasmic reticulum tethering and Ca2+ transfer | (12) |
| Mfn2 | Mouse heart | Regulation of sarcoplasmic reticulum Ca2+ handling. | (13) |
| Opa1 KO | Mouse heart | Mitochondrial dysfunction and structural failure of cristae | (17) |
| Opa1 homozygous KO | Mouse | Embryonic lethal | (18) |
| Opa1 heterozygous KO | Mouse | Death within 4 months | (18) |
| Overexpression of Opa1 | Rat H9C2 cell | Cardiomyocyte protection | (19) |
| Drp1 knockdown | HeLa cell | Attenuation of cristae remodeling and cytochrome c release during apoptosis | (27) |
| Overexpression of Fis1 | HeLa cell | Promotion of clustering of fragmented mitochondria around the nucleus | (29) |
| Overexpression of Drp1 | HeLa cell | Induction of fragmented mitochondria scattered throughout cell | (29) |
| Mfn1/Mfn2/Drp1 KO | Mouse cardiomyocyte | Distortion of sarcomere architecture | (31) |