Table 1.
Coronavirus disease 2019 main diagnostic methods characteristics
Ref.
|
Diagnostic method
|
Sensitivity
|
Specificity
|
Time to result
|
Liu et al[23] | ELISA (IgM/IgG) | 57.9%-90.7% | No cross-reactivity observed | About 100 min |
Cai et al[24] | CLIA (IgM/IgG/IgM and IgG) | 57.2%-81.5% | No cross-reactivity observed | ND |
Montesinos et al[25] | LFA (IgM/IgG/IgM and IgG) | ~70.0% | 95.8%-100% | About 10 min |
Scohy et al[52] | Antigen detection | 30.2% | 100% | About 15 min |
Porte et al[54] | Antigen detection | 93.9% | 100% | About 15 min |
Suo et al[19] | RT-PCR | 94.0% | 100% | ND |
Österdahl et al[26] | RT-LAMP | 80.0% | 73%–100% | About 25 min |
Dao Thi et al[27] | RT-LAMP | 97.5% | 99.7% | About 30 min |
Ai et al[28] | Chest CT | 97.0% | 25% | ND |
ELISA: Enzyme-linked immunosorbent assay; IgA: Immunoglobulin A; IgM: Immunoglobulin M; IgG: Immunoglobulin G; LFA: Lateral flow assay; CLIA: Chemiluminescence immunoassay; RT-PCR: Reverse transcription-polymerase chain reaction; RT-LAMP: Reverse transcription loop-mediated isothermal amplification; CT: Computed tomography; ND: Not described.