Table 2.
Basic information of clinical studies.
| No | Author | Year | Subjects | Gender (M/F) | Age (means±SD) | Disease duration (means±SD) | Disease severity (means±SD) | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | Mihara | 2008 | 20 patients 20 HC | PD: 9/11 HC: 11/9 | PD: 70.7 ± 7.8 HC: 67.6 ± 9.4 | 5.4 ± 3.4 | H&Y score: 2.9 ± 0.8 | 17702627 |
| 2 | Niwa | 2012 | 29 patients 30 HC | PD: 17/12 HC: 16/14 |
PD: 70.4 (mean) HC: 68.9 (mean) | 6.38 ± 4.07 | H&Y score: 2.63 ± 0.92 UPDRS III score: 23.92 ± 15.81 | 21929737 |
| 3 | Stevens | 2012 | 88 patients 77 HC | PD: 56/32 HC: 39/38 |
PD: 69 ± 9 HC: 67 ± 10 | 6 ± 5 | H&Y score: 2 ± 0.7 UPDRS III score: 21 ± 10 | 22910543 |
| 4 | Cen | 2017 | 268 patients 268 HC | PD: 156/112 HC: 168/100 | PD: 60.59 ± 11.11 HC: 59.41 ± 11.11 | EOPD: 3.94 ± 2.32 LOPD: 4.95 ± 4.10 |
H&Y score: EOPD: 1.47 ± 0.51 LOPD: 1.93 ± 0.88 UPDRS III score: EOPD: 11.00 ± 4.63 LOPD: 12.89 ± 7.88 | 28791571 |
| 5 | Sun | 2019 | 127 patients 148 HC | PD: 75/52 HC: 84/64 |
PD: 62.7 ± 12.5 HC: 60.3 ± 13.4 | 4.4 ± 4.1 | UPDRS III score: 17.9 ± 9.2 | 31930038 |
| 6 | Anderson, K. M. | 2020 | 1,314 patients 1,978 HC | - | - | - | - | 32709660 |
| 7 | Huang | 2021 | 205 patients 233 HC | - | - | - | - | 34483877 |
| 8 | Konstantin Nissen | 2022 | 78 patients 28 HC | PD: 39/39 HC: 15/13 |
age at visit: PD: 66.6 ± 9.5 HC: 64.2 ± 7.4 age at onset: PD: 60.4 ± 9.2 | 4.5 (IQR: 3-9) | H&Y score: 2 (median) UPDRS III score: 27.84 ± 14.29 MoCA: 26 (median) | 35026420 |
| 9 | Tian | 2022 | 22 patients 18 HC | PD: 12/10 HC: 13/5 |
EOPD: 40.30 LOPD: 64.23 YHC: 40.30 EHC: 68.25 | EOPD: 2.44 LOPD: 1.8 |
H&Y score: EOPD: 1.31 LOPD: 1.44 UPDRS III score: EOPD: 15.38 LOPD: 21.63 | 35013369 |