Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of the regulations of cell membrane transporters and potential effects on digoxin clearance
|
|
Efflux
|
Influx
|
Effects
|
| Kidney | MDR1: Up-regulated | OATP4C1: Up-regulated | Increase tubule exclusion |
| Intestine | MDR1: Down-regulated | OATP1A4: Down-regulated | Decrease intestinal absorption |
| Liver | MDR1: Up-regulated | OATP4C1: Up-regulated | Increase exclusion into bile duct |
OATP: Organic anion transporting polypeptides; MDR1: Multidrug resistance 1.
