Table 1.
Risk factors associated with portal vein thrombosis after liver resection
| Variables |
Univariate analyses
|
Multivariate analyses
|
||||
|
PVT (+), n = 8
|
PVT (-), n = 227
|
P
value
|
OR
|
95%CI
|
P
value
|
|
| Back ground characteristics | ||||||
| Age | 69.9 ± 3.4 | 67.8 ± 0.6 | 0.54 | |||
| Male sex | 4 (50.0%) | 181 (79.7%) | 0.04 | 0.25 | 0.05-1.29 | 0.10 |
| Hepatocellular carcinoma (+) | 7 (87.5%) | 190 (73.7%) | 0.77 | |||
| Multiple tumor | 2 (25.0%) | 72 (31.7%) | 0.69 | |||
| Heavy drinker | 2 (25.0%) | 55 (24.2%) | 0.96 | |||
| Portal vein embolization | 0 | 12 (5.3%) | 0.50 | |||
| Body mass index | 24.8 ± 1.2 | 23.7 ± 0.2 | 0.39 | |||
| Preoperative anticoagulant therapy | 1 (12.5%) | 10 (4.4%) | 0.29 | 7.95 | 0.32-106.81 | 0.17 |
| Diabetes mellitus | 2 (25.0%) | 92 (40.5%) | 0.38 | |||
| HBsAg (+) | 1 (12.5%) | 39 (17.2%) | 0.73 | |||
| HCVAb (+) | 2 (25.0%) | 52 (22.9%) | 0.89 | |||
| Platelet count as × 104/μL | 18.6 ± 7.8 | 21.4 ± 1.5 | 0.72 | |||
| Albumin in g/dL | 4.2 ± 0.2 | 4.2 ± 0.03 | 0.79 | |||
| Total bilirubin in mg/dL | 0.7 ± 0.2 | 0.7 ± 0.03 | 0.92 | |||
| Prothrombin time, % | 93.8 ± 3.8 | 93.4 ± 0.7 | 0.94 | |||
| D-dimer in ng/mL | 1.7 ± 0.8 | 1.7 ± 0.2 | 0.97 | |||
| ICGR15, % | 15.0 ± 2.2 | 11.7 ± 0.4 | 0.14 | 0.91 | 0.82-1.02 | 0.09 |
| Liver damage B | 0 | 10 (6.3%) | 0.53 | |||
| Procedure | ||||||
| Anatomical resection | 6 (75.0%) | 159 (70.0%) | 0.76 | |||
| Segmentectomy | 0 | 48 (21.2%) | 0.14 | |||
| Sectiontectomy | 6 (75.0%) | 55 (24.2%) | 0.001 | 12.20 | 2.22-115.97 | 0.003 |
| Hemihepatectomy | 0 | 56 (24.7%) | 0.11 | |||
| Surgical outcomes | ||||||
| Operatin time in min | 324 ± 40 | 374 ± 8 | 0.21 | |||
| Hepatic clamping time in min | 76 ± 15 | 89 ± 3 | 0.38 | 1.01 | 0.99-1.03 | 0.56 |
| Blood loss in g | 517 ± 186 | 455 ± 35 | 0.74 | |||
| RBC transfusion | 1 (12.5%) | 13 (5.7%) | 0.43 | |||
| Surgical results | ||||||
| Complication CD ≥ 3a | 3 (37.5%) | 50 (22.0%) | 0.30 | |||
| Bile leakage | 2 (25.0%) | 26 (11.5%) | 0.25 | 3.12 | 0.35-21.58 | 0.28 |
| Mortality | 0 | 2 (0.9%) | 0.79 | |||
| Histological cirrhosis | 1 (12.5%) | 32 (14.1%) | 0.90 | |||
CD: Clavian-Dindo classification; CI: Confidence interval; HBsAg: Hepatitis B surface antigen; HCVAb: Hepatitis C virus antibody; OR: Odds ratio; PVT: Portal vein thrombosis; RBC: Red blood cell.