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. 2022 May 18;10:884467. doi: 10.3389/fcell.2022.884467

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Copyright © 2022 Abreu de Oliveira, El Laithy, Bruna, Annibali and Lluis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of Wnt targeting drugs. Several classes of biological and small molecule Wnt-targeting drugs have been developed and studied for anti-cancer activity. The most important include monoclonal antibodies targeting secreted Wnt ligands (Ipafricet) or their receptors (Vantictumab), tankyrase inhibitors (XAV939, JW55, G007-LK, IWR1), disheveled inhibitors (3289–8625, NSC-668036), PORCN inhibitors (LGK974, IWP2), and inhibitors of the β-catenin:TCF/LEF transcriptional complex (iCRT3. iCRT5, iCRT14, GGP049090, PFK115-584).